{Reference Type}: Journal Article
{Title}: Phytochemical analysis and biological evaluation of essential oils and extracts from Heracleum pastinacifolium subsp. incanum (Boiss. & A.Huet) P.H.Davis, an endemic plant from Turkey.
{Author}: Yuca H;Sefalı A;Aydın B;Karadayı M;Gülşahin Y;Yazıcı A;Karakaya S;Demirci B;Çoban F;Özdemir E;Demir AY;Güvenalp Z;
{Journal}: Nat Prod Res
{Volume}: 0
{Issue}: 0
{Year}: 2024 Jul 4
{Factor}: 2.488
{DOI}: 10.1080/14786419.2024.2372661
{Abstract}: Essential oil content of and phenolic compounds flower-fruit, root, and aerial parts of Heracleum pastinacifolium subsp. incanum were analysed by GC/MS and LC/MS methods, respectively. Antidiabetic, anticholinesterase, and antioxidant activities of flower-fruit, root, aerial parts methanol extracts were evaluated. Apiole (35.0%), myristicine (72.2%), and myristicine (15.1%) were found as major compounds of fruit-flower mixture, root, aerial part essential oils, respectively. Hesperidin was found the highest amount in aerial part and flower-fruit extracts with 8904.2621 ng/mL and 11558.3634 ng/mL values, respectively. Fruit-flower extract showed the highest activity against α-glucosidase (24%). Root extract demonstrating the highest activity (18%) against AChE enzyme. Flowers-fruits mixture methanol extract had a higher % inhibition value on ABTS·+ and DPPH•. Flowers-fruits mixture methanol extract was rich in total phenol, total tannin, and protein content. All the extracts were determined as genetoxically safe according to the results of Ames/Salmonella, Escherichia coli WP2 and Allium cepa assays.