{Reference Type}: Journal Article
{Title}: Impact of minimal invasive extracorporeal circulation on systemic inflammatory response - a randomized trial.
{Author}: Halle DR;Benhassen LL;Søberg KL;Nielsen PF;Kimose HH;Bauer A;Hasenkam JM;Modrau IS;
{Journal}: J Cardiothorac Surg
{Volume}: 19
{Issue}: 1
{Year}: 2024 Jul 3
{Factor}: 1.522
{DOI}: 10.1186/s13019-024-02903-8
{Abstract}: <B>BACKGROUND: </B>Extracorporeal circulation causes a systemic inflammatory response, that may cause postoperative haemodynamic instability and end-organ dysfunction. This study aimed to investigate the impact of minimal invasive extracorporeal circulation (MiECC) on the systemic inflammatory response compared with conventional extracorporeal circulation (CECC).<BR><B>METHODS: </B>Patients undergoing coronary artery bypass grafting were randomized to MiECC (n = 30) and CECC (n = 30). Primary endpoint was tumor necrosis factor-α. Secondary endpoints were other biochemical markers of inflammation (IL1β, IL6 and IL8, C-reactive protein, leukocytes), and markers of inadequate tissue perfusion and tissue damage (lactate dehydrogenase, lactate and creatine kinase-MB). In addition, we registered signs of systemic inflammatory response syndrome, haemodynamic instability, atrial fibrillation, respiratory dysfunction, and infection.<BR><B>RESULTS: </B>Patients treated with MiECC showed significantly lower levels of tumor necrosis factor-α than CECC during and early after extracorporeal circulation (median: MiECC 3.4 pg/mL; CI 2.2-4.5 vs. CECC 4.6 pg/mL; CI 3.4-5.6; p = 0.01). Lower levels of creatine kinase-MB and lactate dehydrogenase suggested less tissue damage. However, we detected no other significant differences in any other markers of inflammation, tissue damage or in any of the clinical outcomes.<BR><B>CONCLUSIONS: </B>Lower levels of TNF-α after MiECC compared with CECC may reflect reduced inflammatory response, although other biochemical markers of inflammation were comparable. Our results suggest better end-organ protection with MiECC compared with CECC. Clinical parameters related to systemic inflammatory response were comparable in this study.<BR><B>BACKGROUND: </B>NCT03216720.