{Reference Type}: Journal Article
{Title}: Metastatic Pleomorphic Carcinoma of the Lung with Extensive Chromosomal Rearrangements: An Autopsy Case with a Literature Review.
{Author}: Matsumoto F;Matsuzawa Adachi M;Yoshida K;Yamashita T;Shiihara J;Fukuchi T;Morikawa H;Hiruta M;Tanno K;Oyama-Manabe N;Oshiro H;Sugawara H;
{Journal}: Intern Med
{Volume}: 0
{Issue}: 0
{Year}: 2024 Jul 4
{Factor}: 1.282
{DOI}: 10.2169/internalmedicine.3478-24
{Abstract}: We herein report a 47-year-old man who presented with progressive paraparesis. Imaging revealed a right upper pulmonary nodule, massive bilateral adrenal metastases, thoracolumbar vertebral osteolysis, and subcutaneous nodules. A biopsy of the right buttock nodule revealed a poorly differentiated metastatic carcinoma with high programmed cell death-ligand 1 expression and extensive chromosomal rearrangements. The patient died 10 days after the initiation of pembrolizumab treatment. Autopsy findings confirmed pulmonary pleomorphic carcinoma with extensive metastases. Quantification of chromosomal rearrangements revealed a jump-up mutation from the normal karyotype, followed by a further incremental increase in the degree of deviation.