{Reference Type}: Journal Article {Title}: Ensuring best practice in genomics education: A theory- and empirically informed evaluation framework. {Author}: Nisselle A;Terrill B;Janinski M;Martyn M;Jordan H;Kaunein N;Metcalfe S;Gaff C; {Journal}: Am J Hum Genet {Volume}: 0 {Issue}: 0 {Year}: 2024 Jun 27 {Factor}: 11.043 {DOI}: 10.1016/j.ajhg.2024.06.004 {Abstract}: Implementation of genomic medicine into healthcare requires a workforce educated through effective educational approaches. However, ascertaining the impact of genomics education activities or resources is limited by a lack of evaluation and inconsistent descriptions in the literature. We aim to support those developing genomics education to consider how best to capture evaluation data that demonstrate program outcomes and effectiveness within scope. Here, we present an evaluation framework that is adaptable to multiple settings for use by genomics educators with or without education or evaluation backgrounds. The framework was developed as part of a broader program supporting genomic research translation coordinated by the Australian Genomics consortium. We detail our mixed-methods approach involving an expert workshop, literature review and iterative expert input to reach consensus and synthesis of a new evaluation framework for genomics education. The resulting theory-informed and evidence-based framework encompasses evaluation across all stages of education program development, implementation and reporting, and acknowledges the critical role of stakeholders and the effects of external influences.