{Reference Type}: Journal Article
{Title}: Atramacronoid A induces the PANoptosis-like cell death of human breast cancer cells through the CASP-3/PARP-GSDMD-MLKL pathways.
{Author}: Li JR;Li LY;Zhang HX;Zhong MQ;Zou ZM;
{Journal}: J Asian Nat Prod Res
{Volume}: 0
{Issue}: 0
{Year}: 2024 Jul 3
{Factor}: 1.61
{DOI}: 10.1080/10286020.2024.2368841
{Abstract}: Breast cancer is the most common malignant tumor and a major cause of mortality among women worldwide. Atramacronoid A (AM-A) is a unique natural sesquiterpene lactone isolated from the rhizome of Atractylodes macrocephala Koidz (known as Baizhu in Chinese). Our study demonstrated that AM-A triggers a specific form of cell death resembling PANoptosis-like cell death. Further analysis indicated that AM-A-induced PANoptosis-like cell death is associated with the CASP-3/PARP-GSDMD-MLKL pathways, which are mediated by mitochondrial dysfunction. These results suggest the potential of AM-A as a lead compound and offer insights for the development of therapeutic agents for breast cancer from natural products.