{Reference Type}: Journal Article
{Title}: Biocellulose-based hydrogel dressing as a strategy for the management of chronic arterial wounds.
{Author}: Moraes CMB;Bassanelli AM;Rodrigues LDS;Barud HDS;Fontes ML;Lourenção PLTA;Castro MCNE;Bertanha M;
{Journal}: Acta Cir Bras
{Volume}: 39
{Issue}: 0
{Year}: 2024
{Factor}: 1.564
{DOI}: 10.1590/acb392924
{Abstract}: <B>OBJECTIVE: </B>To evaluate using a biocellulose-based hydrogel as an adjuvant in the healing process of arterial ulcers.<BR><B>METHODS: </B>A prospective single group quasi-experimental study was carried out with chronic lower limb arterial ulcer patients. These patients received biocellulose-based hydrogel dressings and outpatient guidance on dressing and periodic reassessments. The primary outcomes were the ulcer-healing rate and product safety, which were assessed by ulcer area measured in photographic records of pre-treatment and posttreatment after 7, 30, and 60 days. Secondary outcomes were related to clinical assessment by the quality-of-life scores (SF-36 and EQ-5D) and pain, evaluated by the visual analogue scale (VAS).<BR><B>RESULTS: </B>Seventeen participants were included, and one of them was excluded. Six patients (37%) had complete wound healing, and all patients had a significant reduction in the ulcer area during follow-up (233.6mm2 versus 2.7mm2) and reduction on the score PUSH 3.0 (p < 0.0001). The analysis of the SF-36 and EQ-5D questionnaires showed a statistically significant improvement in almost all parameters analyzed and with a reduction of pain assessed by the VAS.<BR><B>CONCLUSIONS: </B>The biocellulose-based hydrogel was safe and showed a good perspective to promoting the necessary conditions to facilitate partial or complete healing of chronic arterial ulcers within a 60-day follow-up. Quality of life and pain were positively affected by the treatment.