{Reference Type}: Journal Article
{Title}: One-year postpartum weight retention and glucose intolerance in women with prediabetes after gestational diabetes.
{Author}: Mievis V;Minschart C;Myngheer N;Maes T;de Block C;Bochanen N;van Pottelbergh I;Abrams P;Vinck W;Leuridan L;Driessens S;Billen J;Matthys C;Laenen A;Bogaerts A;Mathieu C;Benhalima K;
{Journal}: Diabet Med
{Volume}: 0
{Issue}: 0
{Year}: 2024 Jul 3
{Factor}: 4.213
{DOI}: 10.1111/dme.15400
{Abstract}: <B>OBJECTIVE: </B>To determine risk factors for 1-year postpartum weight retention (PPWR) and glucose intolerance (prediabetes + diabetes) in women with a previous history of gestational diabetes (GDM) and prediabetes in early postpartum.<BR><B>METHODS: </B>In this exploratory analysis of the MELINDA randomized controlled trial, we report data of 167 women with prediabetes at the 6-16 weeks (early) postpartum oral glucose tolerance test after a recent history of GDM.<BR><B>RESULTS: </B>Of all participants, 45% (75) had PPWR >0 kg at 1-year postpartum. Compared to women without PPWR, women with PPWR had higher gestational weight gain [10.5 ± 6.4 vs. 6.5 ± 4.5 kg, p < 0.001], higher BMI (p < 0.01) and a worse metabolic profile (higher waist circumference, worse lipid profile and more insulin resistance) (all p < 0.05) both in early and late postpartum. Of all women with PPWR, 40.0% developed metabolic syndrome, compared to 18.9% of women without late PPWR (p = 0.003). The only independent predictor for late PPWR was weight retention in early postpartum (p < 0.001). Of all participants, 55.1% (92) had glucose intolerance (84 prediabetes, 8 diabetes) 1-year postpartum. Independent predictors for late postpartum glucose intolerance were lower gestational age at start insulin therapy in pregnancy and delivery by caesarean section (resp. p = 0.044 and 0.014).<BR><B>CONCLUSIONS: </B>In women with a previous history of GDM and prediabetes in early postpartum, PPWR in early postpartum was a strong independent predictor for late PPWR, while earlier start of insulin therapy during pregnancy and delivery by caesarean section were independent predictors of glucose intolerance in late postpartum.