{Reference Type}: Case Reports {Title}: A Rare Case of a Pedunculated Lipoma in the Perianal Region: A 20-Year Journey. {Author}: Rekavari SG;Mahakalkar C; {Journal}: Cureus {Volume}: 16 {Issue}: 5 {Year}: 2024 May 暂无{DOI}: 10.7759/cureus.61304 {Abstract}: Lipomas are common benign soft tissue tumors, typically presenting as painless, slow-growing masses of mature adipose tissue. However, their occurrence as pedunculated lesions in the perianal region is rare. We present a case of a 70-year-old male with a 20-year history of a painless, cosmetically concerning mass in the perianal region. Clinical examination and ultrasonographic findings were consistent with a pedunculated lipoma. Surgical excision was performed successfully, and histopathological examination confirmed the diagnosis of lipofibroma. This case highlights the importance of considering unusual presentations of lipomas in the differential diagnosis of perianal masses. It emphasizes the role of surgical excision for symptomatic or cosmetically concerning lesions. Long-term follow-up is essential to monitor for recurrence and ensure optimal patient outcomes.