{Reference Type}: Journal Article
{Title}: Vascular syk-ness: A new role for an old immunological favorite.
{Author}: Fischer R;
{Journal}: J Biol Chem
{Volume}: 300
{Issue}: 7
{Year}: 2024 Jul 28
暂无{DOI}: 10.1016/j.jbc.2024.107517
{Abstract}: Acute respiratory distress syndrome (ARDS) is a deadly clinical presentation in sepsis, COVID, and other lung disorders where vascular fluid leakage is a severe problem. Recent findings by Shadab et al. in the JBC show that a well-known player in immune function, Syk, also regulates vascular leakage in response to sepsis. An existing FDA-approved inhibitor of Syk, fostamatinib, prevents the vascular leakage and improves survival in a mouse sepsis model, providing promise for ARDS treatment in the clinic.