{Reference Type}: Journal Article
{Title}: TROPONIN LEVELS IN TRANSIENT ISCHEMIC ATTACK AND ISCHEMIC STROKE: DOES "TRANSIENT" IN YOUR BRAIN MEAN "BETTER" FOR YOUR HEART?
{Author}: Prandin G;Caruso P;Furlanis G;Rossi L;Cegalin M;Scali I;Mancinelli L;Palacino F;Vincis E;Naccarato M;Manganotti P;
{Journal}: J Stroke Cerebrovasc Dis
{Volume}: 0
{Issue}: 0
{Year}: 2024 Jun 28
{Factor}: 2.677
{DOI}: 10.1016/j.jstrokecerebrovasdis.2024.107844
{Abstract}: <B>OBJECTIVE: </B>transient ischemic attack (TIA) is defined as a transient episode of neurological dysfunction caused by focal brain, spinal cord, or retinal ischemia, with clinical symptoms typically lasting less than one hour, and without evidence of acute infarction. In this type of ischemic event, there are no data about a possible cardiac injury tested with troponin. After a stroke, it is well established the cardiac involvement due to a neuro-inflammatory response (recently defined as Stroke Heart Syndrome). The aim of this study is to compare the troponin elevation after a stroke with TIA.<BR><B>METHODS: </B>this is a retrospective, single center study on 565 patients (73 TIAs, 492 stroke). We collected demographic characteristics, cardiovascular risk factors, cardiac data such as troponin, NT-proBNP, left atrial dilatation, etiology of the ischemic event (TOAST classification).<BR><B>RESULTS: </B>we compare IS and TIA for each TOAST subtype. In all groups no substantial differences were found in demographic and past medical history (p>0.05). However, the maximum troponin level reached were significantly lower in TIAs than IS (p<0.05), except in lacunar etiology were troponin elevation was low also in IS group. We found a trend in favor to IS in the rise and fall troponin elevation over 30% in all the TOAST subgroups, but only in the cryptogenic etiology the difference was significant. About the others cardiac markers of injury, a significant higher rate of elevated NT-proBNP was found in the IS cohort.<BR><B>CONCLUSIONS: </B>troponin level after TIAs is significantly lower than after IS. Troponin elevation after an ischemic event may be more relevant in patients with higher NT-proBNP levels and older age. More studies are needed to better understand the patho-physiology of this phenomenon after an ischemic event.