{Reference Type}: Journal Article
{Title}: Monoterpene-chalcone conjugates and diarylheptanoids isolated from the seeds of Alpinia katsumadai Hayata with cytotoxic activity.
{Author}: You HL;Zhou B;Guo MJ;Zhao XM;Li XL;Shen XC;Zhang NL;
{Journal}: Phytochemistry
{Volume}: 225
{Issue}: 0
{Year}: 2024 Sep 28
{Factor}: 4.004
{DOI}: 10.1016/j.phytochem.2024.114197
{Abstract}: Five undescribed monoterpene-chalcone conjugates (1-5), one undescribed hypothetical precursor of diarylheptanoid (6), two undescribed diarylheptanoids (7-8), and fourteen known compounds (9-22) were isolated from the seeds of Alpinia katsumadai. Their structures were elucidated through the interpretation of HRESIMS, NMR, ECD, and X-ray diffraction data. MTT assays on human cancer cell lines (HepG2, A549, SGC7901, and SW480) revealed that compounds 3-8, 11, and 13 exhibited broad-spectrum antiproliferative activities with IC50 values ranging from 3.59 to 21.78 μM. B cell lymphoma 2 was predicted as the target of sumadain C (11) by network pharmacology and verified by homogeneous time-resolved fluorescence assay and molecular docking.