{Reference Type}: Journal Article
{Title}: Incidence of catheter-related thrombosis and its association with outcome in critically ill patients: A prospective observational study.
{Author}: Smit JM;Haaksma ME;Heldeweg MLA;Adamse DS;Choi KF;Jonker SRL;Rijpkema J;van Zanten FJL;Vlaar APJ;Müller MCA;Girbes ARJ;Heunks LMA;Tuinman PR;
{Journal}: Thromb Res
{Volume}: 241
{Issue}: 0
{Year}: 2024 Jun 18
{Factor}: 10.407
{DOI}: 10.1016/j.thromres.2024.109068
{Abstract}: <B>BACKGROUND: </B>Incidence of central venous catheter (CVC)-related thrombosis in critically ill patients remains ambiguous and its association with potential hazardous sequelae unknown. The primary aim of the study was to evaluate the epidemiology of CVC-related thrombosis; secondary aims were to assess the association of catheter-related thrombosis with catheter-related infection, pulmonary embolism and mortality.<BR><B>METHODS: </B>This was a single-center, prospective observational study conducted at a tertiary intensive care unit (ICU) in the Netherlands. The study population consisted of CVC placements in adult ICU patients with a minimal indwelling time of 48 h. CVC-related thrombosis was diagnosed with ultrasonography. Primary outcomes were prevalence and incidence, incidence was reported as the number of cases per 1000 indwelling days.<BR><B>RESULTS: </B>173 CVCs in 147 patients were included. Median age of patients was 64.0 [IQR: 52.0, 72.0] and 71.1 % were male. Prevalence of thrombosis was 0.56 (95 % CI: 0.49, 0.63) and incidence per 1000 indwelling days was 65.7 (95 % CI: 59.0, 72.3). No association with catheter-related infection was found (p = 0.566). There was a significant association with pulmonary embolism (p = 0.022). All 173 CVCs were included in the survival analysis. Catheter-related thrombosis was associated with a lower 28-day mortality risk (hazard ratio: 0.39, 95 % CI: 0.17, 0.87).<BR><B>CONCLUSIONS: </B>In critically ill patients, prevalence and incidence of catheter-related thrombosis were high. Catheter-related thrombosis was not associated with catheter-related infections, but was associated with pulmonary embolism and a decreased mortality risk.