{Reference Type}: Journal Article
{Title}: Polyfunctionalized organoselenides: New synthetic approach from seleno-containing cyanohydrins and anti-melanoma activity.
{Author}: Clara da Silva Durigon M;Renata Caitano Visnheski B;Braz Júnior O;Christina Thomas J;Fogagnoli Simas F;Piovan L;
{Journal}: Bioorg Med Chem Lett
{Volume}: 0
{Issue}: 0
{Year}: 2024 Jun 26
{Factor}: 2.94
{DOI}: 10.1016/j.bmcl.2024.129860
{Abstract}: A series of seleno-containing polyfunctionalized compounds was synthesized exploring cyanohydrin chemistry, including α-hydroxy esters, α-hydroxy acids, 1,2-diols, and 1,2-diacetates, with yields ranging from 26 up to 99 %. The cytotoxicity of all synthesized compounds was then evaluated using a non-tumor cell line (BALB/3T3 murine fibroblasts), and those deemed non-cytotoxic had their anti-melanoma activity evaluated using B16-F10 murine melanoma cells. These assays identified two compounds with selective cytotoxic activity against the tested melanoma cell line, showing a potential anti-melanoma application.