{Reference Type}: Journal Article
{Title}: The anti-aging effects of Chlorella polysaccharide extract in Caenorhabditis elegans.
{Author}: Feng ST;You CT;Pan ZK;Gao WY;Wang DD;Hu LL;
{Journal}: Nat Prod Res
{Volume}: 0
{Issue}: 0
{Year}: 2024 Jun 28
{Factor}: 2.488
{DOI}: 10.1080/14786419.2024.2371562
{Abstract}: Chlorella has a variety of biological activities, and it is worth further exploring its pharmacological effects. In this study, we investigated the antioxidant and anti-ageing activities of Chlorella polysaccharide extract (CPE). Further studies revealed that CPE exhibited anti-ageing, and antioxidant activities in vivo, including an extended Caenorhabditis elegans stress resistance, decreased deposition of lipofuscin, and reduced effects of amyloid β protein on mobility, decreased levels of reactive oxygen species and increased activity of antioxidant enzymes. Moreover, it dramatically increased the expression of anti-stress and longevity genes and reduced the expression of ageing-related genes; therefore, it was hypothesised that the mechanism of the age-delaying effect of CPE was related to the insulin signalling pathway. In summary, CPE could delay ageing and provide a new avenue for the application and development of CPE.