{Reference Type}: Journal Article
{Title}: Prognostic Value of Self-Reported Subjective Exercise Capacity in Patients With Acute Dyspnea.
{Author}: Belkin M;Wussler D;Michou E;Strebel I;Kozhuharov N;Sabti Z;Nowak A;Shrestha S;Lopez-Ayala P;Prepoudis A;Stefanelli S;Schäfer I;Mork C;Albus M;Danier I;Simmen C;Zimmermann T;Diebold M;Breidthardt T;Mueller C;
{Journal}: JACC Adv
{Volume}: 2
{Issue}: 3
{Year}: 2023 May
暂无{DOI}: 10.1016/j.jacadv.2023.100342
{Abstract}: <B>UNASSIGNED: </B>Self-reported exercise capacity is a well-established prognostic measure in stable ambulatory patients with cardiac and pulmonary disease.<BR><B>UNASSIGNED: </B>The authors aimed to directly compare the prognostic accuracy of quantified self-reported exercise capacity using the Duke Activity Status Index (DASI) with the established objective disease-severity marker B-type natriuretic peptide (BNP) in patients presenting with acute dyspnea to the emergency department.<BR><B>UNASSIGNED: </B>The DASI was obtained in a prospective multicenter diagnostic study recruiting unselected patients presenting with acute dyspnea to the emergency department. The prognostic accuracy of DASI and BNP for 90-day and 720-day all-cause mortality was evaluated using C-index.<BR><B>UNASSIGNED: </B>Among 1,019 patients eligible for this analysis, 75 (7%) and 297 (29%) patients died within 90 and 720 days after presentation, respectively. Unadjusted hazard ratios (HRs) and multivariable adjusted hazard ratios (aHRs) for 90- and 720-day mortality increased continuously from the fourth (best self-reported exercise capacity) to the first DASI quartile (worst self-reported exercise capacity). For 720-day mortality the HR of the first quartile vs the fourth was 9.1 (95% CI, 5.5-14.9) vs (aHR: 6.1, 95% CI: 3.7-10.1), of the second quartile 6.4 (95% CI: 3.9-10.6) vs (aHR: 4.4, 95% CI: 2.6-7.3), while of the third quartile the HR was 3.2 (95% CI: 1.9-5.5) vs (aHR: 2.4, 95% CI: 1.4-4.0). The prognostic accuracy of the DASI score was high, and higher than that of BNP concentrations (720-day mortality C-index: 0.67 vs 0.62; P = 0.024).<BR><B>UNASSIGNED: </B>Quantification of self-reported subjective exercise capacity using the DASI provides high prognostic accuracy and may aid physicians in risk stratification. (Basics in Acute Shortness of Breath EvaLuation [BASEL V] Study [BASEL V]; NCT01831115).