{Reference Type}: Journal Article
{Title}: Mac-2 binding protein glycosylation isomer as a novel predictor of early recurrence after resection for hepatocellular carcinoma.
{Author}: Yugawa K;Maeda T;Tsuji K;Shimokawa M;Sakai A;Yamaguchi S;Konishi K;Hashimoto K;
{Journal}: Surg Today
{Volume}: 0
{Issue}: 0
{Year}: 2024 Jun 28
{Factor}: 2.54
{DOI}: 10.1007/s00595-024-02885-z
{Abstract}: <B>OBJECTIVE: </B>Hepatocellular carcinoma (HCC) frequently recurs after radical resection, resulting in a poor prognosis. This study assessed the prognostic value of Mac-2 binding protein glycosylation isomer (M2BPGi) for early recurrence (ER) in patients with HCC.<BR><B>METHODS: </B>Patients who underwent radical resection for HCC between 2015 and 2021. HCC recurrence within one year after curative resection was defined as ER.<BR><B>RESULTS: </B>The 150 patients were divided into two groups: non-ER (116, 77.3%) and ER (34, 22.7%). The ER group had a lower overall survival rate (p < 0.0001) and significantly higher levels of M2BPGi (1.06 vs. 2.74 COI, p < 0.0001) than the non-ER group. High M2BPGi levels (odds ratio [OR] 1.78, 95% confidence interval [CI] 1.31-2.41, p < 0.0001) and a large tumor size (OR 1.31, 95% CI, 1.05-1.63; p = 0.0184) were identified as independent predictors of ER. M2BPGi was the best predictor of ER according to a receiver operating characteristic (ROC) analysis (area under the ROC curve 0.82, p < 0.0001).<BR><B>CONCLUSIONS: </B>M2BPGi can predict ER after surgery and is useful for risk stratification in patients with HCC.