{Reference Type}: Journal Article
{Title}: Secondary pseudohypoaldosteronism: a 15-year experience and a literature review.
{Author}: Moreno Sánchez A;García Atarés Á;Molina Herranz D;Antoñanzas Torres I;Romero Salas Y;Ruiz Del Olmo Izuzquiza JI;
{Journal}: Pediatr Nephrol
{Volume}: 0
{Issue}: 0
{Year}: 2024 Jun 28
{Factor}: 3.651
{DOI}: 10.1007/s00467-024-06428-z
{Abstract}: <B>BACKGROUND: </B>Secondary pseudohypoaldosteronism (S-PHA) is a rare condition resulting from renal tubular resistance to aldosterone in children with urinary tract infection (UTI) and/or nephrourological malformations. It is characterized by nonspecific symptoms but with the potential for life-threatening complications. We aim to evaluate the clinical manifestations, diagnostic approach, and therapeutic interventions in children with S-PHA, along with a review of recent publications.<BR><B>METHODS: </B>A retrospective observational descriptive study was conducted on S-PHA cases diagnosed over the last 15 years at a tertiary pediatric nephrology unit. The literature for the last 10 years was reviewed.<BR><B>RESULTS: </B>Twelve patients (10 males, 6 days to 6 months) were identified. Weight loss was the main reason for consultation (50%). Ninety-two percent of patients had an underlying nephrourological pathology and 62% concomitant confirmed UTI. Seven out of 12 children were admitted to the PICU. A subsequent extrapontine myelinolysis was observed in one patient as neurological sequelae. Twenty-one articles related to S-PHA have been identified on PubMed and Embase.<BR><B>CONCLUSIONS: </B>S-PHA should be considered in infants under 6 months of age with UTI and/or CAKUT. Obstructive anomalies and vesicoureteral reflux can be found, affecting both unilateral and bilateral systems. Early medical and surgical interventions are crucial and require close monitoring to avoid iatrogenic complications.