{Reference Type}: Journal Article
{Title}: Source localization comparison and combination of OPM-MEG and fMRI to detect sensorimotor cortex responses.
{Author}: An N;Gao Z;Li W;Cao F;Wang W;Xu W;Wang C;Xiang M;Gao Y;Wang D;Yu D;Ning X;
{Journal}: Comput Methods Programs Biomed
{Volume}: 254
{Issue}: 0
{Year}: 2024 Sep 21
{Factor}: 7.027
{DOI}: 10.1016/j.cmpb.2024.108292
{Abstract}: <B>OBJECTIVE: </B>The exploration of various neuroimaging techniques have become focal points within the field of neuroscience research. Magnetoencephalography based on optically pumped magnetometers (OPM-MEG) has shown significant potential to be the next generation of functional neuroimaging with the advantages of high signal intensity and flexible sensor arrangement. In this study, we constructed a 31-channel OPM-MEG system and performed a preliminary comparison of the temporal and spatial relationship between magnetic responses measured by OPM-MEG and blood-oxygen-level-dependent signals detected by functional magnetic resonance imaging (fMRI) during a grasping task.<BR><B>METHODS: </B>For OPM-MEG, the β-band (15-30 Hz) oscillatory activities can be reliably detected across multiple subjects and multiple session runs. To effectively localize the inhibitory oscillatory activities, a source power-spectrum ratio-based imaging method was proposed. This approach was compared with conventional source imaging methods, such as minimum norm-type and beamformer methods, and was applied in OPM-MEG source analysis. Subsequently, the spatial and temporal responses at the source-level between OPM-MEG and fMRI were analyzed.<BR><B>RESULTS: </B>The effectiveness of the proposed method was confirmed through simulations compared to benchmark methods. Our demonstration revealed an average spatial separation of 10.57 ± 4.41 mm between the localization results of OPM-MEG and fMRI across four subjects. Furthermore, the fMRI-constrained OPM-MEG localization results indicated a more focused imaging extent.<BR><B>CONCLUSIONS: </B>Taken together, the performance exhibited by OPM-MEG positions it as a potential instrument for functional surgery assessment.