{Reference Type}: Journal Article
{Title}: Development and validation of a frailty index for use in the osteoarthritis initiative.
{Author}: O'Brien MW;Maxwell SP;Moyer R;Rockwood K;Theou O;
{Journal}: Age Ageing
{Volume}: 53
{Issue}: 6
{Year}: 2024 06 1
{Factor}: 12.782
{DOI}: 10.1093/ageing/afae125
{Abstract}: The Osteoarthritis Initiative (OAI) evaluates the development and progression of osteoarthritis. Frailty captures the heterogeneity in aging. Use of this resource-intensive dataset to answer aging-related research questions could be enhanced by a frailty measure.<BR>To: (i) develop a deficit accumulation frailty index (FI) for the OAI; (ii) examine its relationship with age and compare between sexes, (iii) validate the FI versus all-cause mortality and (iv) compare this association with mortality with a modified frailty phenotype.<BR>OAI cohort study.<BR>North America.<BR>An FI was determined for 4,755/4,796 and 4,149/4,796 who had a valid FI and frailty phenotype.<BR>Fifty-nine-variables were screened for inclusion. Multivariate Cox regression evaluated the impact of FI or phenotype on all-cause mortality at follow-up (up to 146 months), controlling for age and sex.<BR>Thirty-one items were included. FI scores (0.16 ± 0.09) were higher in older adults and among females (both, P < 0.001). By follow-up, 264 people had died (6.4%). Older age, being male, and greater FI were associated with a higher risk of all-cause mortality (all, P < 0.001). The model including FI was a better fit than the model including the phenotype (AIC: 4,167 vs. 4,178) and was a better predictor of all-cause mortality than the phenotype with an area under receiver operating characteristic curve: 0.652 vs. 0.581.<BR>We developed an FI using the OAI and validated it in relation to all-cause mortality. The FI may be used to study aging on clinical, functional and structural aspects of osteoarthritis included in the OAI.