{Reference Type}: Case Reports
{Title}: A CASE OF HYPONATREMIA DUE TO PITUITARY METASTASIS OF LUNG CANCER.
{Author}: Taskaldiran I;Gokbulut P;Koc G;Fırat S;Omma T;Kuşkonmaz SM;Culha C;
{Journal}: Acta Endocrinol (Buchar)
{Volume}: 19
{Issue}: 4
{Year}: 2023 Oct-Dec
{Factor}: 1.104
{DOI}: 10.4183/aeb.2023.501
{Abstract}: <B>UNASSIGNED: </B>Hyponatremia is a common electrolyte abnormality.<BR><B>UNASSIGNED: </B>We report a patient who presented with hyponatremia and diagnosed as small cell lung cancer metastatic to hypothalamus and pituitary.<BR><B>UNASSIGNED: </B>A 68 year old male patient was admitted with fever and cough and pneumonia was considered. Serum sodium level was 113 mmol/L. Syndrome of inappropriate ADH (SIADH) is considered. Thyroid function tests and cortisol levels pointed out a central deficiency in both axes. Pituitary MRI was performed and a hypothalamic and pituitary mass were observed. Prednisolone therapy was started followed by L thyroxine replacement. A chest computer tomography (CT) was taken 2 weeks later revealed a mass lesion. Bronchoscopic biopsy was performed and histopathological diagnosis of the tumor was reported as small cell lung cancer.<BR><B>UNASSIGNED: </B>Many mechanisms were considered as the cause of hyponatremia in our patient. SIADH, secondary adrenal insufficiency and secondary hypothyroidism due to pituitary metastasis are possible causes.<BR><B>UNASSIGNED: </B>The reason of hyponatremia is sometimes complex. When the underlying causes of hyponatremia are not evaluated in detail, many diagnoses can be missed.