{Reference Type}: Journal Article
{Title}: Obesity and thyroid cancer: unraveling the connection through a systematic review and meta-analysis of cohort studies.
{Author}: Abiri B;Ahmadi AR;Valizadeh A;Abbaspour F;Valizadeh M;Hedayati M;
{Journal}: J Diabetes Metab Disord
{Volume}: 23
{Issue}: 1
{Year}: 2024 Jun
暂无{DOI}: 10.1007/s40200-024-01425-3
{Abstract}: <B>UNASSIGNED: </B>The relationship between adiposity indicators and thyroid cancer (TC) risk has garnered increasing attention due to the rising prevalence of obesity and its potential impact on cancer incidence. We conducted a comprehensive meta-analysis to investigate this association across various effect measures.<BR><B>UNASSIGNED: </B>Until July 2022, a comprehensive search of databases was conducted to identify cohort studies that assessed the association between adiposity and the development of TC. Meta-analysis was performed using random effects models. Subgroup analyses were conducted to explore heterogeneity. Publication bias was assessed using Begg's tests.<BR><B>UNASSIGNED: </B>A systematic literature search identified 27 eligible studies reporting odds ratios (OR), relative risks (RR), or hazard ratios (HR) as effect measures. Pooling the studies irrespective of the effect measure, a significant positive association between adiposity indicators and TC risk was observed, yielding an effect estimate of 1.16 (95% CI 1.12-1.21). The combined effect estimate for OR/RR studies was 1.10 (95%CI 1.04-1.17), while HR studies yielded an effect estimate of 1.20 (95%CI 1.13-1.26). Subgroup analyses revealed associations across different age groups, obesity indices, and regions, with some variations based on effect measure. Meta-regression identified follow-up duration as a confounding factor only in HR studies.<BR><B>UNASSIGNED: </B>The synthesis of 27 studies with diverse designs and populations underscores a robust positive association between adiposity and TC risk, providing compelling evidence for the potential role of increased adiposity in TC development.<BR><B>UNASSIGNED: </B>The online version contains supplementary material available at 10.1007/s40200-024-01425-3.