{Reference Type}: Journal Article
{Title}: Comprehensive Analysis of Novel Synergistic Antioxidant Formulations: Insights into Pharmacotechnical, Physical, Chemical, and Antioxidant Properties.
{Author}: Neacșu SM;Mititelu M;Ozon EA;Musuc AM;Iuga IDM;Manolescu BN;Petrescu S;Pandele Cusu J;Rusu A;Surdu VA;Oprea E;Lupuliasa D;Popescu IA;
{Journal}: Pharmaceuticals (Basel)
{Volume}: 17
{Issue}: 6
{Year}: 2024 May 27
{Factor}: 5.215
{DOI}: 10.3390/ph17060690
{Abstract}: (1) Background: Oxidative stress plays a pivotal role in the pathogenesis of various diseases, including neurodegenerative disorders, cardiovascular diseases, cancer, and diabetes, highlighting the pressing need for effective antioxidant interventions. (2) Methods: In this study, we aimed to develop and characterise two novel antioxidant formulations, F3 and F4, as therapeutic interventions for oxidative stress-related conditions. (3) Results: The physicochemical characterisation, preformulation analysis, formulation, preparation of filling powders for capsules, capsule content evaluation, and antioxidant activity assessment of the two novel antioxidant formulations were assessed. These formulations comprise a combination of well-established antioxidants like quercetin, biotin, coenzyme Q10, and resveratrol. Through comprehensive testing, the formulations' antioxidant efficacy, stability, and potential synergistic interactions were evaluated. (4) Conclusions: The findings underscore the promising potential of these formulations as therapeutic interventions for oxidative stress-related disorders and highlight the significance of antioxidant interventions in mitigating their progression.