{Reference Type}: Journal Article
{Title}: Stereoselective Solid-State Synthesis of Biologically Active Cyclobutane and Dicyclobutane Isomers via Conformation Blocking and Transference.
{Author}: Qin Z;Gu Y;Young D;Hu F;Luo Z;
{Journal}: Molecules
{Volume}: 29
{Issue}: 12
{Year}: 2024 Jun 19
{Factor}: 4.927
{DOI}: 10.3390/molecules29122909
{Abstract}: Conformations in the solid state are typically fixed during crystallization. Transference of "frozen" C=C conformations in 3,5-bis((E)-2-(pyridin-4-yl)vinyl)methylbenzene (CH3-3,5-bpeb) by photodimerization selectively yielded cyclobutane and dicyclobutane isomers, one of which (Isomer 2) exhibited excellent in vitro anti-cancer activity towards T-24, 7402, MGC803, HepG-2, and HeLa cells.