{Reference Type}: Journal Article
{Title}: Selective Oxidative Cleavage of Benzyl C-N Bond under Metal-Free Electrochemical Conditions.
{Author}: Huang J;Li X;Liu P;Wei Y;Liu S;Ma X;
{Journal}: Molecules
{Volume}: 29
{Issue}: 12
{Year}: 2024 Jun 15
{Factor}: 4.927
{DOI}: 10.3390/molecules29122851
{Abstract}: With the growing significance of green chemistry in organic synthesis, electrochemical oxidation has seen rapid development. Compounds undergo oxidation-reduction reactions through electron transfer at the electrode surface. This article proposes the use of electrochemical methods to achieve cleavage of the benzyl C-N bond. This method selectively oxidatively cleaves the C-N bond without the need for metal catalysts or external oxidants. Additionally, primary, secondary, and tertiary amines exhibit good adaptability under these conditions, utilizing water as the sole source of oxygen.