{Reference Type}: Case Reports
{Title}: Germ Cell Tumor of the Testis: Lethal Subtypes of a Curable Cancer.
{Author}: Jackson JC;Sanchez D;Johns AC;Campbell MT;Aydin AM;Gokden N;Maraboyina S;Muesse JL;Ward JF;Pisters LL;Zacharias NM;Guo CC;Tu SM;
{Journal}: J Clin Med
{Volume}: 13
{Issue}: 12
{Year}: 2024 Jun 12
{Factor}: 4.964
{DOI}: 10.3390/jcm13123436
{Abstract}: Germ cell tumor of the testis (GCT) is a curable cancer even when it is widely metastatic; however, outcomes can differ based on tumor histology. Chemo-resistance in certain phenotypes, such as teratoma and yolk sac tumor, contributes to poor clinical outcomes in some patients with GCT. Despite this resistance to S-YSTemic therapy, many of these tumor subtypes remain amenable to surgical resection and possible cure. In this study, we report on a series of seven patients highlighting two chemo-resistant subtypes of nonseminomatous germ cell tumor (NSGCT), sarcomatoid yolk sac tumor (S-YST), and epithelioid trophoblastic tumor (ETT) for which early resection rather than additional salvage chemotherapy or high-dose intense chemotherapy might provide a superior clinical outcome and enhance cure rate.