{Reference Type}: Journal Article
{Title}: Mouldable Collagen-Tricalciumphosphate Is a Safe Carrier for Local Antibiotics-Short-Term Results in Revision Hip Arthroplasty.
{Author}: Hanusrichter Y;Gebert C;Frieler S;Moellenbeck B;Dudda M;Wessling M;Theil C;
{Journal}: Antibiotics (Basel)
{Volume}: 13
{Issue}: 6
{Year}: 2024 May 30
{Factor}: 5.222
{DOI}: 10.3390/antibiotics13060510
{Abstract}: <B>BACKGROUND: </B>Improving local antibiotic delivery is a promising approach to improve infection control and potentially shorten systemic treatment in periprosthetic joint infection (PJI). This study investigates the use of an antibiotic-loaded, mouldable collagen-tricalciumphosphate composite in treatment of hip PJI.<BR><B>METHODS: </B>124 application cases in 79 patients were included from a referral centre; systemic adverse infects, local complications, and infection control were analysed.<BR><B>RESULTS: </B>In most cases, either vancomycin or meropenem were used. Pathogens were previously known in 82 (66%) cases with polymicrobial infection in 20 (25%) patients. There were no cases of hypercalcaemia. Acute kidney injure was present in 14 (11%) cases. Chronic kidney failure persisted in two cases. During a mean follow-up of 12 (SD 9.3; range 3-35) months, implant survival was achieved in 73 (92%) patients; revision due to PJI was performed in 19 cases.<BR><B>CONCLUSIONS: </B>Mouldable collagen-tricalciumphosphate composite bone substitute as a local antibiotic carrier in revision hip arthroplasty appears to be a valid option for local antibiotic delivery without systemic complications. Implant survival of 92% supports the hypothesis that local antibiotic therapy is an important component in the treatment of PJI.