{Reference Type}: English Abstract
{Title}: [Analysis of Risk Factors for Pulmonary Infection in Patients with Acute Leukemia after Chemotherapy].
{Author}: Zhang XP;Xi YM;
{Journal}: Zhongguo Shi Yan Xue Ye Xue Za Zhi
{Volume}: 32
{Issue}: 3
{Year}: 2024 Jun
暂无{DOI}: 10.19746/j.cnki.issn.1009-2137.2024.03.043
{Abstract}: <B>OBJECTIVE: </B>To investigate the risk factors of pulmonary infection in patients with acute leukemia (AL) after chemotherapy.<BR><B>METHODS: </B>A total of 294 patients with AL were collected and divided into infection group (n=93) and control group (n=201) according to whether the pulmonary infection occurred after chemotherapy. Analyze the correlation between sociodemographic data (sex, age, BMI), clinical data (disease type, ECOG score, invasive procedure, underlying disease, hormone therapy, empirical use of antibiotics, prognosis stratification, chemotherapy intensity, primitive cell count, white blood cell count, neutrophil count, duration of granulocyte deficiency, platelet count, hemoglobin, and albumin and pulmonary infection after chemotherapy. COX regression method was used to analyze the risk factors of pulmonary infection in AL patients after chemotherapy.<BR><B>RESULTS: </B>Among 294 patients with AL, 11 died within 30 days after pulmonary infection. There were statistically significant differences in age, smoking history, ECOG score, invasive procedure, hormone therapy, empirical use of antibiotics, prognosis stratification, chemotherapy intensity, primitive cell count, neutrophil count, duration of granulocyte deficiency, platelet count, hemoglobin, albumin and fasting blood glucose between the 2 groups (P <0.05). COX regression analysis showed that smoking history, invasive procedure, unexperienced use of antibiotics, poor prognosis, long duration of granulocytopenia, low platelet level and low albumin were high risk factors for pulmonary infection in AL patients after chemotherapy (P <0.05).<BR><B>CONCLUSIONS: </B>Smoking, invasive procedures, unexperienced use of antibiotics, poor prognosis, long duration of granulodeficiency, low platelet levels and low albumin are risk factors for pulmonary infection in AL patients after chemotherapy.<BR><B>UNASSIGNED: </B>急性白血病患者化疗后肺部感染的危险因素分析.<BR><B>UNASSIGNED: </B>探讨急性白血病（AL）患者化疗后肺部感染的危险因素。.<BR><B>UNASSIGNED: </B>收集294例AL患者作为研究对象，根据化疗后是否肺部感染分为感染组 （93例）和对照组（201例），分析社会人口学资料（性别、年龄、BMI）、临床资料（疾病类型、ECOG评分、侵入性操作、基础疾病、激素治疗、经验性使用抗生素、预后分层、化疗强度、原始细胞计数、白细胞计数、中性粒细胞计数、粒缺持续时间、血小板计数、血红蛋白、白蛋白、空腹血糖）与AL化疗后肺部感染的相关性，采用COX回归法分析急性白血病患者化疗后肺部感染的危险因素。.<BR><B>UNASSIGNED: </B>294例AL患者肺部感染后30 d内死亡病例为11例。感染组与未感染组患者在年龄、吸烟史、ECOG评分、侵入性操作、激素治疗、经验性使用抗生素、预后分层、化疗强度、原始细胞计数、中性粒细胞计数、粒缺持续时间、血小板计数、血红蛋白、白蛋白、空腹血糖方面差异有统计学意义（P <0.05）。COX回归分析结果显示，吸烟史、侵入性操作、未预防性使用抗生素、预后不良、粒缺持续时间长、血小板水平低、白蛋白低是AL患者化疗后肺部感染的高危因素（P <0.05）。.<BR><B>UNASSIGNED: </B>吸烟、侵入性操作、未预防性使用抗生素、预后不良、粒缺持续时间长、血小板水平低、白蛋白低是AL患者化疗后肺部感染的高危因素。.