{Reference Type}: Journal Article
{Title}: Association of trajectories and cumulative exposure of antenatal depression with high birth weight.
{Author}: Wang J;Xu J;Wu P;Ye YX;Lai Y;Wang Y;Dong Y;Zhao B;Hu Y;Liu G;Pan A;Pan XF;
{Journal}: J Affect Disord
{Volume}: 362
{Issue}: 0
{Year}: 2024 Oct 1
{Factor}: 6.533
{DOI}: 10.1016/j.jad.2024.06.059
{Abstract}: <B>BACKGROUND: </B>Inconsistent associations between antenatal depression and fetal birth weight were reported previously, and little is known about the dynamic changes and long-term cumulative effect of antenatal depression during pregnancy.<BR><B>METHODS: </B>Participants were from the Tongji-Huaxi-Shuangliu Birth Cohort. Depressive symptoms were measured using the Edinburgh Postnatal Depression Scale in early, middle, and late pregnancy respectively. Trajectories of antenatal depression were assessed using the latent class mixed model. The percentage of days with depression (PDD) and frequency of antenatal depression were measured to assess the cumulative exposure. Multivariable logistic regression models were used to evaluate the associations of antenatal depression with macrosomia and large for gestational age (LGA).<BR><B>RESULTS: </B>We identified four distinct trajectories, including the low stable group (n = 1,327, 27.99 %), the moderate stable group (n = 2,610, 55.05 %), the peak group (n = 407, 8.58 %), and the valley group (n = 397, 8.37 %). Compared with the low stable group, the valley group showed a higher risk of macrosomia (OR, 1.98; 95 % CI, 1.17, 3.38) and LGA (OR, 1.44; 95 % CI, 1.002, 2.09); the peak group showed a higher risk of LGA (OR, 1.52; 95 % CI, 1.07, 2.16), but the association was not significant for macrosomia (OR, 1.47; 95 % CI, 0.85, 2.55). Consistently, cumulative antenatal depression was also positively associated with the risks of macrosomia and LGA.<BR><B>CONCLUSIONS: </B>The antenatal depression was self-reported using a screening scale and information bias could not be ruled out.<BR><B>CONCLUSIONS: </B>Certain trajectories and cumulative exposure of antenatal depression were associated with higher risks of high birth weight.