{Reference Type}: Journal Article
{Title}: Electrochemical Synthesis of Itaconic Acid Derivatives via Chemodivergent Single and Double Carboxylation of Allenes with CO2.
{Author}: Brunetti A;Garbini M;Autuori G;Zanardi C;Bertuzzi G;Bandini M;
{Journal}: Chemistry
{Volume}: 30
{Issue}: 49
{Year}: 2024 Sep 2
{Factor}: 5.02
{DOI}: 10.1002/chem.202401754
{Abstract}: Leveraging electrochemistry, a new synthesis of non-natural derivatives of itaconic acid is proposed by utilizing carbon dioxide (CO2) as a valuable C1 synthon. An electrochemical cross-electrophile coupling between allenoates and CO2 was targeted, allowing for the synthesis of both mono- and di-carboxylation products in a catalyst- and additive-free environment (yields up to 87 %, 30 examples). Elaboration of the model mono-carboxylation product, and detailed cyclovoltammetric, as well as mechanistic analyses complete the present investigation.