{Reference Type}: Journal Article
{Title}: Domain 5 of Beta 2 glycoprotein I: Friend or foe in health? Context matters.
{Author}: Giannakopoulos B;Krilis SA;
{Journal}: Clin Immunol
{Volume}: 265
{Issue}: 0
{Year}: 2024 Jun 23
{Factor}: 10.19
{DOI}: 10.1016/j.clim.2024.110282
{Abstract}: Beta 2 glycoprotein I (β2GPI) is the major autoantigen in the antiphospholipid syndrome, an autoimmune disorder characterized by thrombotic and obstetric complications. The autoantibodies that target beta 2 glycoprotein I are pathogenic and contribute to disease pathogenesis. The β2GPI molecule is composed of 5 domains that are numbered 1 through to 5. Autoantibodies bind mainly to domain 1 whereas the majority of the biological functions of the β2GPI molecule in diverse processes such as apoptotic cell clearance, complement regulation, lipopolysaccharide clearance and anticoagulation have been localised to domain 5 and its unique biochemistry, reviewed in this article. The role of purified domain 5 peptide as a potential therapeutic agent in APS and ischemia reperfusion injury is discussed.