{Reference Type}: Journal Article
{Title}: Changes in blood catecholamines during induction of general anesthesia in patients with post-induction hypotension undergoing laparoscopic cholecystectomy: A single-center prospective cohort study.
{Author}: Yao Y;Kong X;Chen X;Zhang Y;Liu X;Wang X;
{Journal}: PLoS One
{Volume}: 19
{Issue}: 6
{Year}: 2024
{Factor}: 3.752
{DOI}: 10.1371/journal.pone.0305980
{Abstract}: <B>BACKGROUND: </B>Post-induction hypotension (PIH) often occurs during general anesthesia induction. This study aimed to investigate blood catecholamine levels during induction of general anesthesia in patients with PIH undergoing laparoscopic cholecystectomy.<BR><B>METHODS: </B>This prospective study included 557 adult patients who underwent laparoscopic cholecystectomy under general anesthesia. PIH was defined as a greater than 20% decrease in systolic blood pressure from the pre-induction value, a systolic arterial pressure of less than 90 mmHg, or both. Plasma concentrations of epinephrine and norepinephrine during the induction of general anesthesia were determined using enzyme-linked immunosorbent assay. Multivariate logistic regression analysis evaluated the association between the clinical factors and PIH.<BR><B>RESULTS: </B>Of the 557 patients, 390 had PIH, and the remaining 167 were allocated to the non-PIH group. Changes in blood adrenaline, noradrenaline levels, or both were more pronounced in the PIH than in the non-PIH group (p<0.05). Age, body mass index, a history of hypertension, preoperative systolic blood pressure, and propofol or sufentanil dose were independent predictors of PIH.<BR><B>CONCLUSIONS: </B>The changes of blood catecholamines in patients with more stable hemodynamics during the induction of general anesthesia are smaller than that in patients with post-induction hypotension.<BR><B>BACKGROUND: </B>ChiCTR2200055549, 12/01/2022.