{Reference Type}: Journal Article
{Title}: Global brain connectivity: Test-retest stability and association with biological and neurocognitive variables.
{Author}: Del Mauro G;Li Y;Wang Z;
{Journal}: J Neurosci Methods
{Volume}: 409
{Issue}: 0
{Year}: 2024 Sep 22
{Factor}: 2.987
{DOI}: 10.1016/j.jneumeth.2024.110205
{Abstract}: <B>BACKGROUND: </B>Global brain connectivity (GBC) enables measuring brain regions' functional connectivity strength at rest by computing the average correlation between each brain voxel's time-series and that of all other voxels.<BR><B>METHODS: </B>We used resting-state fMRI (rs-fMRI) data of young adult participants from the Human Connectome Project (HCP) dataset to explore the test-retest stability of GBC, the brain regions with higher or lower GBC, as well as the associations of this measure with age, sex, and fluid intelligence. GBC was computed by considering separately the positive and negative correlation coefficients (positive GBC and negative GBC).<BR><B>RESULTS: </B>Test-retest stability was higher for positive compared to negative GBC. Areas with higher GBC were located in the default mode network, insula, and visual areas, while regions with lower GBC were in subcortical regions, temporal cortex, and cerebellum. Higher age was related to global reduction of positive GBC. Males displayed higher positive GBC in the whole brain. Fluid intelligence was associated to increased positive GBC in fronto-parietal, occipital and temporal regions.<BR><B>CONCLUSIONS: </B>Compared to previous works, this study adopted a larger sample size and tested GBC stability using data from different rs-fMRI sessions. Moreover, these associations were examined by testing positive and negative GBC separately.<BR><B>CONCLUSIONS: </B>Lower stability for negative compared to positive GBC suggests that negative correlations may reflect less stable couplings between brain regions. Our findings indicate a greater importance of positive compared to negative GBC for the associations of functional connectivity strength with biological and neurocognitive variables.