{Reference Type}: Journal Article
{Title}: Clinical and mycological analysis of colonization by Candida spp. in oral leukoplakia and oral lichen planus.
{Author}: Novo VM;Feletti MP;Maifrede SB;da Fonseca JZ;Cayô R;Gonçalves SS;Grão-Velloso TR;
{Journal}: Braz J Microbiol
{Volume}: 0
{Issue}: 0
{Year}: 2024 Jun 24
{Factor}: 2.214
{DOI}: 10.1007/s42770-024-01416-9
{Abstract}: <B>OBJECTIVE: </B>This study aims to analyze the prevalence of Candida spp. colonization in oral leukoplakia and oral lichen planus lesions, verify the influence of systemic and local factors, besides identify and determine the in vitro antifungal susceptibility profile of Candida species.<BR><B>METHODS: </B>Samples were collected by swabbing from oral lesions and healthy mucosa and cultured on Sabouraud Dextrose and CHROMagar® Candida plates. Species identification was confirmed with MALDI-TOF MS analysis.<BR><B>RESULTS: </B>Candida spp. was found in 36.8% of cases of oral leukoplakia and 18.2% of cases of oral lichen planus. Candida albicans was the only species found in oral lichen planus lesions (n = 2, 100%) and the most prevalent in oral leukoplakia (n = 5, 76.4%). Among the non-albicans Candida species found in oral leukoplakia were C. parapsilosis (n = 2, 25.5%) and C. tropicalis (n = 1, 14.1%). Candida isolates were susceptible to all antifungals tested.<BR><B>CONCLUSIONS: </B>C. albicans was the most commonly found species in the studied lesions. No correlation was found between systemic and local factors with positive cases of oral lichen planus. However, smoking and alcohol consumption may be associated with positive cases of oral leukoplakia, especially the non-homogeneous clinical form. In addition, there is a possible predisposition to associated Candida colonization in cases of epithelial dysplasia found in oral leukoplakia. The antifungal medications tested showed excellent efficacy against isolates.