{Reference Type}: Journal Article
{Title}: Self-Illuminating Nanoagonist Simultaneously Induces Dual Cell Death Pathways via Death Receptor Clustering for Cancer Therapy.
{Author}: You Y;Zhu L;Song Y;Hu J;Chen M;Zhang J;Xu X;Huang X;Wu X;Lu J;Tong X;Ji JS;Du YZ;
{Journal}: ACS Nano
{Volume}: 18
{Issue}: 26
{Year}: 2024 Jul 2
{Factor}: 18.027
{DOI}: 10.1021/acsnano.4c03767
{Abstract}: Inducing death receptor 5 (DR5) clustering holds particular promise in tumor-specific therapeutics because it could trigger an apoptotic cascade in cancerous cells. Herein, we present a tumor microenvironment H2O2-responsive self-illuminating nanoagonist, which could induce dual tumor cell death pathways through enhancing DR5 clustering. By conjugating DR5 ligand peptides onto the surfaces of self-illuminating nanoparticles with cross-linking capacity, this strategy not only provides scaffolds for ligands to bind receptors but also cross-links them through photo-cross-linking. This strategy allows for efficient activation of DR5 downstream signaling, initiating the extrinsic apoptosis pathway and immunogenic cell death of tumor cells, and contributes to improved tumor-specific immune responses, resulting in enhanced antitumor efficacy and minimized systemic adverse effects.