{Reference Type}: Case Reports
{Title}: Talaromyces marneffei: A challenging diagnosis in a kidney transplant patient.
{Author}: Luo S;Yan P;Wang X;Ren X;Sun K;Guo L;Lv J;Su X;Zhao K;Chen J;Wang R;
{Journal}: Clin Case Rep
{Volume}: 12
{Issue}: 7
{Year}: 2024 Jul
暂无{DOI}: 10.1002/ccr3.9028
{Abstract}: <B>UNASSIGNED: </B>In addition to post-transplant lymphoproliferative disorders, it is necessary to be alert to the drug-resistant bacteria or fungal infection, especially Talaromyces marneffei, in kidney transplant patients who have failed antibiotic treatment and whose PET-CT indicates high metabolic mass in the transplanted kidney with a large number of other organs and lymph nodes.<BR><B>UNASSIGNED: </B>Talaromyces marneffei (TM) is a rare pathogenic fungus that primarily affects individuals with compromised immune systems. Post-transplant lymphoproliferative disorders (PTLD) are serious complications that can occur after solid organ and cell transplantation. Both TM infection and PTLD can invade the monocyte-macrophage system and often manifest as extranodal masses. This case report describes a kidney transplant patient who presented with symptoms of frequent, urgent, and painful urination over 6 months. Pulmonary CT scans revealed multiple nodules, and PET-CT demonstrated enlarged lymph nodes in the lungs and the transplanted kidney. The clinical manifestations closely mimicked those of PTLD. The confirmation of TM was achieved through pathogen metagenomic next-generation sequencing and renal biopsy. Unfortunately, despite receiving treatment with antifungal agents, anti-infective therapy, the patient's condition did not respond favorably, ultimately resulting in their unfortunate demise due to COVID-19.