{Reference Type}: Case Reports
{Title}: Holocord pilocytic astrocytoma in a young woman with intracranial extension: case report and review of the MRI characteristics.
{Author}: Kiani Salmi S;Dehghanian A;Taherifard A;Dehghan A;
{Journal}: Spinal Cord Ser Cases
{Volume}: 10
{Issue}: 1
{Year}: 2024 Jun 22
暂无{DOI}: 10.1038/s41394-024-00656-z
{Abstract}: <B>BACKGROUND: </B>Pilocytic astrocytoma is a low-grade glioma more frequently seen in patients <20. It is pretty uncommon in the spinal cord. Rarely, astrocytoma may involve the most or total length of the spinal cord; in that case, they are called "holo-cord astrocytoma." In this case report, we are reporting the third holo-cord pilocytic astrocytoma in an adult patient and the first with an extension to the Magendie foramen.<BR><B>METHODS: </B>We presented a 24-year-old woman with complaints of progressively worsening neck and back pain since one year ago. The patient's MRI showed a very large intradural and intramedullary cystic lesion with a solid component within the spinal cord extending from the medulla to the conus medullaris. Partial resection of the solid part of the cervical portion of the tumor was performed. Histopathological evaluation of the resected tumor segments was compatible with grade I pilocytic astrocytoma. After one year of follow-up, neck and back pain has reduced, and neurological functions have improved.<BR><B>CONCLUSIONS: </B>Spinal cord pilocytic astrocytoma may present as a holo-cord tumor and can rarely extend to the intracranial fossa. Although this tumor does not arise from the central canal, in this case, it was extended through the Magendie foramen. Symptoms could be subtle despite extensive cord involvement. On MRI, this tumor presents as an intramedullary holo-cord cystic lesion intermixed with a solid component with a variable enhancement of the solid component.