{Reference Type}: Journal Article
{Title}: Disulfiram-loaded CuO2 nanocarriers for enhanced synergistic chemodynamic chemotherapy.
{Author}: Hu W;Yang L;Liao H;Sun D;Ouyang XK;Wang N;Yang G;
{Journal}: J Colloid Interface Sci
{Volume}: 674
{Issue}: 0
{Year}: 2024 Jun 21
{Factor}: 9.965
{DOI}: 10.1016/j.jcis.2024.06.147
{Abstract}: Disulfiram (DSF) metabolites exhibit antitumor properties when bound to Cu2+. This combination also promotes the generation of reactive oxygen species (ROS), ultimately leading to tumor cell death. In this study, CuO2 served as a carrier for DSF, forming a dual-drug delivery system with Cu2+ and DSF encapsulated in polydopamine (PDA). In the final delivery system, CuO2 (DSF-CuO2@PDA) was hydrolyzed at the tumor site, releasing both Cu2+ and H2O2. Cu2+ reacts with DSF metabolites to form Bis(diethyldithiocarbamate)-Cu (CuET), which triggers a Fenton-like reaction that generates ROS. Chemotherapy and chemodynamic therapy exhibited significant tumor-suppressive capabilities, with an inhibition rate of 61 %. In addition, the DSF-CuO2@PDA complex demonstrated superlative tumor-targeting ability and biocompatibility.