{Reference Type}: Journal Article
{Title}: The impact of clinically relevant health conditions on psychosocial outcomes in survivors of childhood cancer: results of the DCCSS-LATER study.
{Author}: Maas A;Maurice-Stam H;Feijen LEAM;Teepen JC;van der Aa-van Delden AM;Streefkerk N;van Dulmen-den Broeder E;Tissing WJE;Loonen JJ;van der Pal HJH;de Vries ACH;van den Heuvel-Eibrink MM;Ronckers C;Neggers S;Bresters D;Louwerens M;Versluys BAB;van der Heiden-van der Loo M;Kremer LCM;Grootenhuis M; ;
{Journal}: J Cancer Surviv
{Volume}: 0
{Issue}: 0
{Year}: 2024 Jun 22
{Factor}: 4.062
{DOI}: 10.1007/s11764-024-01617-z
{Abstract}: <B>OBJECTIVE: </B>Investigate the association between presence, number and type of clinically relevant health conditions and a range of psychosocial outcomes (emotional, social, cognitive, physical) in survivors of childhood cancer (CCS).<BR><B>METHODS: </B>CCS from the Dutch Childhood Cancer Survivor Study (DCCSS)-LATER cohort (diagnosed between 1963-2001, attained age ≥ 18, diagnosed < 18, ≥ 5 years since diagnosis) completed a questionnaire on health conditions (2013-2014), and questionnaires on psychosocial outcomes (2017-2020): Hospital Anxiety and Depression Scale, Short form 36, TNO-AZL Questionnaire for Adult Health-Related Quality of Life, and the Self-Rating Scale for Post-Traumatic Stress Disorder. Associations among health conditions and psychosocial outcomes were assessed with regression analysis, adjusting for attained age, sex, and time since diagnosis, and adjusting for multiple testing (p < 0.004).<BR><B>RESULTS: </B>A total of 1437 CCS, mean age 36.3 years, 51.1% female, ≥ 15 years since diagnosis, completed questionnaires on health and psychosocial outcomes. CCS with a clinically relevant health condition, and those with more conditions had worse emotional, social, and physical outcomes; regression coefficients were small to moderate. CCS with gastro-intestinal conditions, endocrine, nervous systems, eye, or ear conditions, and especially those with secondary malignant neoplasms, reported worse psychosocial functioning; regression coefficients were small/moderate to large.<BR><B>CONCLUSIONS: </B>Health care professionals should be aware of the increased risk for psychosocial problems among CCS with health conditions, especially for survivors with secondary malignant neoplasms, gastro-intestinal, endocrine, nervous system, eye, and ear conditions. CCS may benefit from psychological interventions to develop coping strategies to manage health conditions and psychosocial consequences of the cancer trajectory.