{Reference Type}: Journal Article
{Title}: Cyanoacrylate versus suture as flap closure methods in mandibular third molar surgery: a split-mouth randomized controlled clinical study.
{Author}: Santmartí-Oliver M;Bazal-Bonelli S;Sánchez-Labrador L;Beca-Campoy T;Pérez-González F;Cobo-Vázquez CM;Madrigal Martínez-Pereda C;Meniz-García C;
{Journal}: Med Oral Patol Oral Cir Bucal
{Volume}: 29
{Issue}: 4
{Year}: 2024 Jul 1
暂无{DOI}: 10.4317/medoral.26375
{Abstract}: <B>BACKGROUND: </B>Sutures have been the standard flap closure method of choice following mandibular third molar surgery but can lead to some complications. Tissue adhesives, including cyanoacrylate, have emerged as alternative flap closure method in this surgery to overcome such drawbacks. However, limited clinical trials can be found. Therefore, the aim of this clinical study was to compare two methods of flap closure in mandibular third molar surgery, cyanoacrylate and 4/0 silk sutures, by assessing post-operative outcome measures (pain, swelling, trismus, and healing) and patient-reported outcome measures (PROMs).<BR><B>METHODS: </B>A randomized split-mouth clinical trial was designed, in which mandibular third molar (M3M) extractions were performed, where the control side flap was closed with 4/0 silk sutures and the test side flap with cyanoacrylate. Swelling, pain, trismus, healing, and PROMs were recorded post-operatively. These variables were analyzed by means of the nonparametric Mann-Whitney U test, using SPSS statistical software version 28.0.0 (IBM® SPSS®, Chicago, IL, USA). For all results, a 95% confidence interval was recorded (significance level p < 0.05, two-tailed).<BR><B>RESULTS: </B>A total of 17 patients were recruited and 34 mandibular third molar extractions were performed. No statistically significant differences were found in terms of swelling, pain, trismus, healing, and PROMs between both groups (p<0.05).<BR><B>CONCLUSIONS: </B>No statistically significant differences were found between flap closure with 4/0 silk sutures and cyanoacrylate, in terms of surgical post-operative outcomes and PROMs. However, further studies with larger sample sizes are required to be able to affirm it with greater certainty.