{Reference Type}: Journal Article {Title}: In-silico study of the biomechanical effects of proximal-fibular osteotomy on knee joint contact pressure in varus-valgus misalignment. {Author}: Morales-Avalos JE;Morales-Avalos R;Martínez-Guajardo KV;Perelli S;Monllau JC;Sánchez Egea AJ;Serrancolí G; {Journal}: Med Eng Phys {Volume}: 129 {Issue}: 0 {Year}: 2024 07 {Factor}: 2.356 {DOI}: 10.1016/j.medengphy.2024.104185 {Abstract}: The aim of this work is to investigate in-silico the biomechanical effects of a proximal fibular osteotomy (PFO) on a knee joint with different varus/valgus deformities on the progression of knee osteoarthritis (KOA). A finite element analysis (FEA) of a human lower extremity consisting of the femoral, tibial and fibular bones and the cartilage connecting them was designed. The FEA was performed in a static standing primitive position to determine the contact pressure (CP) distribution and the location of the center of pressure (CoP). The analysis examined the relationship between these factors and the degree of deformation of the hip-knee angle in the baseline condition. The results suggested that PFO could be a simple and effective surgical treatment for patients with associated genu varum. This work also reported that a possible CP homogenization and a CoP correction can be achieved for medial varus deformities after PFO. However, it reduced its effectiveness for tibial origin valgus misalignment and worsened in cases of femoral valgus misalignment.