{Reference Type}: Journal Article
{Title}: Community-based Intervention for Obstructive Sleep Apnea in the General Population: A Randomized Controlled Trial.
{Author}: Wang L;Ou Q;Shan G;Zhan W;Huang J;Lin Q;Li J;Liu Y;Xu Y;Chen C;Chen W;
{Journal}: Sleep
{Volume}: 0
{Issue}: 0
{Year}: 2024 Jun 21
{Factor}: 6.313
{DOI}: 10.1093/sleep/zsae132
{Abstract}: <B>OBJECTIVE: </B>To investigate the engagement and health outcomes of community-based intervention for obstructive sleep apnea (OSA) in the general population.<BR><B>METHODS: </B>We conducted a 3-month randomized controlled trial in two communities in southern China. We initially screened the general population for high-risk OSA and further diagnosis using home sleep testing. Eligible participants were randomly (1:1) assigned to either a control or continuous positive airway pressure-based integrated intervention group. The primary outcomes were multimodal indicators reflecting health outcomes, including health-related quality of life (Short Form-36 [SF-36]), sleep-related symptoms, and cardiometabolic risk.<BR><B>RESULTS: </B>Of the 2,484 participants screened, 1,423 identified as having high-risk OSA were considered for telephone invitations to participate in the trial. Of these, 401 participants responded positively (28.2%), 279 were diagnosed with OSA, and 212 were randomized. The intervention significantly improved several domains of SF-36, including physical functioning (intergroup difference, 2.8; P=0.003), vitality (2.3; P=0.031), and reported health transition (6.8; P=0.005). Sleep-related symptoms, including Epworth Sleepiness Scale (-0.7; P=0.017), Fatigue Severity Scale (-3.0; P=0.022), Insomnia Severity Index (-1.8; P<0.001), and Pittsburgh Sleep Quality Index (-0.7; P=0.032), also showed significant improvements. Although the intervention did not significantly alter glycolipid metabolism, ventricular function, or cardiac structural remodeling, it achieved a significant reduction in systolic (-4.5 mmHg; P=0.004) and diastolic blood pressure (-3.7 mmHg; P<0.001).<BR><B>CONCLUSIONS: </B>Community-based intervention for previously undiagnosed OSA in the general population yielded improvements in health-related quality of life, sleep-related symptoms, and blood pressure. However, engagement in the intervention program was low.