{Reference Type}: Journal Article
{Title}: TRPS1 expression in breast angiosarcoma.
{Author}: Pancsa T;Pósfai B;Schubert A;Almási S;Papp E;Chien YC;Kálmán E;Kovács KA;Kulka J;Varga L;Cserni G;Kuthi L;
{Journal}: Virchows Arch
{Volume}: 0
{Issue}: 0
{Year}: 2024 Jun 20
{Factor}: 4.535
{DOI}: 10.1007/s00428-024-03852-2
{Abstract}: Angiosarcoma (AS) of the breast, a rare mesenchymal neoplasm, exhibits distinct forms based on etiological and genetic features. While cases with typical clinical presentation and morphology allow for a straightforward diagnosis, challenges arise when clinical data are scarce, diagnostic material is limited, or morphological characteristics overlap with other tumors, including undifferentiated carcinomas. The trichorhinophalangeal syndrome protein 1 (TRPS1), once regarded as highly specific for breast carcinomas, now faces doubts regarding its reliability. This study explores TRPS1 expression in breast AS. Our investigation revealed that 60% of AS cases displayed TRPS1 labeling, contrasting with the 40% lacking expression. Scoring by four independent readers established a consensus, designating 12/35 ASs as unequivocally TRPS1-positive. However, uncertainty surrounded nine further cases due to a lack of reader agreement (being substantial as reflected by a kappa value of 0.76). These findings challenge the perceived specificity of TRPS1, shedding light on its presence in a noteworthy proportion of breast ASs. Consequently, the study underscores the importance of a comprehensive approach in evaluating breast ASs and expands the range of entities within the differential diagnosis associated with TRPS1 labeling.