{Reference Type}: Journal Article
{Title}: Immunoglobulin G4-related disease mimicking an appendiceal neoplasm: a case report.
{Author}: Kim D;Lee J;Jung M;Lee SL;Yim K;Chong Y;Alam MR;Seo KJ;
{Journal}: J Int Med Res
{Volume}: 52
{Issue}: 6
{Year}: 2024 Jun
{Factor}: 1.573
{DOI}: 10.1177/03000605241260540
{Abstract}: Immunoglobulin G4-related disease (IgG4-RD) is a fibroinflammatory condition characterized by chronic activation of the immune system and a tendency to form tumorous lesions. IgG4-RD is frequently characterized by the presence of tumor-like masses affecting multiple organs and is easily mistaken for a malignant neoplasm. However, IgG4-RD affecting the appendix is extremely rare, with only seven cases reported previously. We report the case of a woman in her early 60s who presented with insidious abdominal pain and radiological findings mimicking appendiceal neoplasms. After diagnosing appendiceal neoplasms, surgery was performed. The patient had a serum IgG4 concentration of <1.35 g/L, which did not satisfy one of the three revised comprehensive diagnostic criteria for IgG4-RD. A pathological examination was conducted, and the patient was diagnosed with appendiceal IgG4-RD. To the best of our knowledge, there have been no previously reported cases of IgG4-RD affecting the appendix in patients with low serum IgG4 concentrations. This report may prove beneficial for the future understanding of IgG4-RD and for the revision of diagnostic and treatment strategies.