{Reference Type}: Journal Article
{Title}: Diarylheptanoid glycosides from Dioscorea nipponica rhizomes.
{Author}: Meng QL;Chi J;Li YX;Zhang WJ;Zhang LX;Wang ZM;Dai LP;
{Journal}: Fitoterapia
{Volume}: 177
{Issue}: 0
{Year}: 2024 Sep 17
{Factor}: 3.204
{DOI}: 10.1016/j.fitote.2024.106078
{Abstract}: A group of previously undescribed diarylheptanoids with mono/di-glucose substitution, diodiarylheptosides A-F (1-6), together with six known diarylheptanoids (7-12) were isolated from the rhizomes of Dioscorea nipponica. Their structures were established by comprehensive UV, IR, HR-ESI-MS and NMR analyses, and their absolute configurations were determined by a comparison of calculated and experimental ECD, some with optical rotations, after acid-hydrolysis. Moreover, bioassay results showed that compounds 3 and 11 exhibited stronger NO inhibitions on lipopolysaccharides-induced RAW 264.7 cells, with the IC50 values of 14.91 ± 0.62 and 12.78 ± 1.12 μM.