{Reference Type}: Journal Article
{Title}: New insights gained from cellular landscape changes in myocarditis and inflammatory cardiomyopathy.
{Author}: Wang W;Jia H;Hua X;Song J;
{Journal}: Heart Fail Rev
{Volume}: 0
{Issue}: 0
{Year}: 2024 Jun 19
{Factor}: 4.654
{DOI}: 10.1007/s10741-024-10406-w
{Abstract}: Advances in the etiological classification of myocarditis and inflammatory cardiomyopathy (ICM) have reached a consensus. However, the mechanism of myocarditis/ICM remains unclear, which affects the development of treatment and the improvement of outcome. Cellular transcription and metabolic reprogramming, and the interactions between cardiomyocytes and non-cardiomyocytes, such as the immune cells, contribute to the process of myocarditis/ICM. Recent efforts have been made by multi-omics techniques, particularly in single-cell RNA sequencing, to gain a better understanding of the cellular landscape alteration occurring in disease during the progression. This article aims to provide a comprehensive overview of the latest studies in myocarditis/ICM, particularly as revealed by single-cell sequencing.