{Reference Type}: Journal Article
{Title}: Delivery of Experimental mRNA Vaccine Encoding the RBD of SARS-CoV-2 by Jet Injection.
{Author}: Kisakov DN;Kisakova LA;Sharabrin SV;Yakovlev VA;Tigeeva EV;Borgoyakova MB;Starostina EV;Zaikovskaya AV;Rudometov AP;Rudometova NB;Karpenko LI;Ilyichev AA;
{Journal}: Bull Exp Biol Med
{Volume}: 176
{Issue}: 6
{Year}: 2024 Apr 19
{Factor}: 0.737
{DOI}: 10.1007/s10517-024-06107-x
{Abstract}: We studied a needle-free jet injection delivery of an experimental mRNA vaccine encoding the receptor-binding domain of the SARS-CoV-2 S protein (mRNA-RBD). Immunization of BALB/c mice with mRNA-RBD by a needle-free jet injector induced high levels of antibodies with virus-neutralizing activity and a virus-specific T-cell response. The immune response was low in the group of mice that received intramuscular injection of mRNA-RBD. The effectiveness of this simple and safe method of mRNA delivering has been demonstrated. Thus, jet injection of mRNA vaccine can be a good alternative to lipid nanoparticles.