{Reference Type}: Journal Article
{Title}: The Role of HSP90 Molecular Chaperones in Depression: Potential Mechanisms.
{Author}: Fan X;Sun L;Qin Y;Liu Y;Wu S;Du L;
{Journal}: Mol Neurobiol
{Volume}: 0
{Issue}: 0
{Year}: 2024 Jun 19
{Factor}: 5.682
{DOI}: 10.1007/s12035-024-04284-4
{Abstract}: Major depressive disorder (MDD) is characterized by high rates of disability and death and has become a public health problem that threatens human life and health worldwide. HPA axis disorder and neuroinflammation are two common biological abnormalities in MDD patients. Hsp90 is an important molecular chaperone that is widely distributed in the organism. Hsp90 binds to the co-chaperone and goes through a molecular chaperone cycle to complete its regulation of the client protein. Numerous studies have demonstrated that Hsp90 regulates how the HPA axis reacts to stress and how GR, the HPA axis' responsive substrate, matures. In addition, Hsp90 exhibits pro-inflammatory effects that are closely related to neuroinflammation in MDD. Currently, Hsp90 inhibitors have made some progress in the treatment of a variety of human diseases, but they still need to be improved. Further insight into the role of Hsp90 in MDD provides new ideas for the development of new antidepressant drugs targeting Hsp90.