{Reference Type}: Journal Article
{Title}: Low-dose decitabine plus venetoclax as post-transplant maintenance for high-risk myeloid malignancies.
{Author}: Parks K;Diebold K;Salzman D;Di Stasi A;Al-Kadhimi Z;Espinoza-Gutarra M;Bhatia R;Jamy O;
{Journal}: EJHaem
{Volume}: 5
{Issue}: 3
{Year}: 2024 Jun
暂无{DOI}: 10.1002/jha2.915
{Abstract}: Relapse remains a major cause of treatment failure following allogeneic stem cell transplantation (allo-SCT) for patients with acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). We retrospectively investigated low-dose decitabine and venetoclax (DEC/VEN) as post-transplant maintenance in 26 older patients with AML and MDS. The cumulative incidence of day 100 gIII-IV acute graft versus host disease (GVHD) and 1-year moderate-severe chronic GVHD was 5% and 26%, respectively. One patient relapsed 14 m after transplant. The 1-year non-relapse mortality and survival were 11% and 84%, respectively. DEC/VEN is a safe and potentially effective strategy to reduce the risk of post-transplant relapse.