{Reference Type}: Journal Article
{Title}: QoL during KTd or KRd induction followed by K maintenance or observation in transplant noneligible patients with newly diagnosed multiple myeloma: Longitudinal and cross-sectional analysis of the randomized AGMT 02 study.
{Author}: Ludwig H;Melchardt T;Schweitzer I;Sormann S;Schreder M;Andel J;Hartmann B;Zojer N;Schöffmann L;Gunsilius E;Podar K;Egle A;Willenbacher W;Wöll E;Ruckser R;Bozic B;Krauth MT;Petzer A;Schmitt C;Machherndl-Spandl S;Agis H;Fillitz M;Wang SY;Knop S;Greil R;
{Journal}: EJHaem
{Volume}: 5
{Issue}: 3
{Year}: 2024 Jun
暂无{DOI}: 10.1002/jha2.925
{Abstract}: Understanding the impact of induction and maintenance therapy on patients' quality of life (QoL) is important for treatment selection. This study aims to compare patient-reported QoL between patients treated with KTd or KRd induction therapy and K maintenance therapy or observation. QoL was assessed using the EORTC QOL-C 30 and QOL-MY20 questionnaires in the AGMT-02 study, in which 123 patients with newly diagnosed transplant ineligible multiple myeloma were randomized to nine cycles of either KTd or KRd induction therapy, followed by 12 cycles of K maintenance therapy, or observation. Longitudinal assessments showed statistically significant improvements in global health-related QoL, various disease symptoms and pain for both treatment regimens. KTd improved insomnia and fatigue, and KRd improved physical functioning. Cross-sectional comparisons indicated a "slight" superiority of KTd over KRd in several scales, with the exception of higher neuropathy scores with KTd. During maintenance, longitudinal comparisons showed no statistically significant changes. Cross-sectional comparisons revealed a "slight" improvement in cognitive functioning during carfilzomib therapy, but a worsening in most other QoL scales. Induction therapy led to improvements in most QoL items, while maintenance therapy with K maintenance was associated with "slight" or "moderate" impairments in several QoL scales compared with the observation group.