{Reference Type}: Journal Article {Title}: The Effectiveness of Mind-Body Intervention on Psychological Well-Being during the COVID-19 Pandemic: A Pilot Pre-Post Interventional Study. {Author}: Peterson A;Borsellino P;Davidson R;Ezeanolue E;Lagasca G;Diaz J;Batra K;Weisman A; {Journal}: Healthcare (Basel) {Volume}: 12 {Issue}: 11 {Year}: 2024 May 31 {Factor}: 3.16 {DOI}: 10.3390/healthcare12111125 {Abstract}: The pandemic highlighted the need for alternative, more accessible access to mental health interventions that can be readily administered remotely. The purpose of this pre-post-interventional study was to evaluate the effectiveness of a virtual mind-body medicine training course on stress, anxiety, and depression levels. University employees and members of the Las Vegas community were recruited via self-selection and snowball sampling and subjected to online mind-body practice sessions in December of 2020. Stress, anxiety, depression, and quality of life were assessed pre- and post-intervention using standardized psychometric valid tools. The paired t-test and related samples marginal homogeneity tests were used for continuous and categorical outcomes, respectively. Depression and stress scores were significantly decreased (p < 0.001). Mean scores of professional quality of life improved post-intervention compared to pre-intervention (p = 0.03). A significantly larger proportion of participants reported no depression or stress post-intervention compared with pre-intervention (p < 0.001, p = 0.003, respectively.) This study suggests that virtual mind-body practices had a pronounced impact on stress and depression levels during the pandemic. These findings support virtual, online-guided mind-body medicine training as an effective intervention that can be administered virtually to reduce stress and depression symptoms.